imc data (Mendeley Ltd)
Structured Review

Imc Data, supplied by Mendeley Ltd, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/imc data/product/Mendeley Ltd
Average 90 stars, based on 1 article reviews
Images
1) Product Images from "Endocannabinoids and their receptors modulate endometriosis pathogenesis and immune response"
Article Title: Endocannabinoids and their receptors modulate endometriosis pathogenesis and immune response
Journal: eLife
doi: 10.7554/eLife.96523
Figure Legend Snippet: ( A ) The imaging mass cytometry (IMC) data collection and analysis workflow outlines the steps involved in gaining comprehensive insights into the spatial distribution of immune cells and relevant cell types within undecidualized (UnD) and decidualized (DD) EM-like lesions of WT, CNR1 k/o, and CNR2 k/o mice. ( B, C ) Representative images showing the single-cell segmentation performed following the acquisition of two regions of interest (ROI) per section (three biological samples per genotype) and segmentation quality of the data after segmentation analysis was conducted, respectively. ( D ) Non-linear dimensionality reduction after batch effect correction showed distinct expression patterns of immune cells and cell state markers between UnD and DD lesions. DD lesions from the CNR1 k/o and CNR2 k/o mice showed expression pattern that was significantly different from the DD lesions of WT mice, as well as compared to UnD lesions among different genotypes. ( E ) Uniform manifold approximation and projection (UMAP) dimensionality reduction highlighted key cell types and differences in composition between UnD and DD lesions. DD lesions exhibited increased stroma and fibroblasts, decreased epithelial cells, and heightened macrophage infiltration compared to UnD lesions.
Techniques Used: Imaging, Mass Cytometry, Expressing